Приложение 2. Статистическая обработка данных Значения полученных результатов,%

Статистическая обработка данных

	Значения полученных результатов,%	Х	σ	tкр
АКТ 4мг АКТ 8мг	91; 73; 78; 81; 114; 120	90,7	17,4	1,3
66; 50; 56; 62; 65; 67	59,7	6,47	15,3
ЗИФ 4мг ЗИФ 8мг	84; 81; 89; 82; 112; 80; 116	92,0	14,2	1,4
59; 62; 64; 57; 61; 59; 68	61,4	3,45	27,7
АКТ 8мг ЗИФ 8мг	79,7; 72; 74,5; 74; 71; 76; 70	72,5	2,20	30,9
59,5; 54; 65; 53; 58; 63; 50	57,5	5,06	20,9
ЗИФ 8мг АКТ 8мг	69,5; 76; 69; 65; 65; 72; 74; 66	69,5	3,9	20,7
54,5; 57; 47; 58; 48; 52; 56; 48	52,5	4,15	30,4

ЛИТЕРАТУРА

1. Владимиров Ю.А. Активированная хемилюминесценция и биолюминесценция как инструмент в медико-биологических исследованиях//Соросовский образовательный журнал. 2001.Том7, №1.С.16-23

2. Владимиров Ю.А., Проскурнина Е.В. Свободные радикалы и клеточная хемилюминесценция. Успехи биологической химии//2009. Том 49.С.341-388

3. Влияние индапамида на уровень радикалов кислорода, продуцируемых фагоцитами крови пациентов с сердечной недостаточностью/Асташкин Е.И.[и др.]// Российский кардиологический журнал.2012. № 4(96).C.43-47

4. Тугушева Ф.А, Зубина И.М.,Митрофанова О.В.Оксидативный стресс и хроническая болезнь почек//Нефрология.2007.Том 11,№3.C.29-47

5. A novel and unusual case of chronic granulomatous disease in a child with a homozygous 36-bp deletion in the CYBA gene [A22(0)] leading to the activation of a cryptic splice site in intron 4/ Stasia MJ[and others]//Hum Genet.2002. №110.P.444–450

6. A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury: the role of NADH as an electron donor/Zhang Z.[and others]//Free Radic Res.1998№.28.P.151–164

7. Activation of NADPH Oxidase During Progression of Cardiac Hypertrophy to Failure/Jian-Mei Li[and others]//Hypertension.2002.№40.P.477-484

8. Allopurinol improves endothelial dysfunction in chronic heart failure/Farquharson CAJ. [and others]// Circulation.2002. №106.P.221–226

9. Babior BM, Lambeth JD,Nauseef W. The neutrophil NADPH oxidase// Arch Biochem Biophys.2002. № 397.P.342–344

10. Christopher A Papaharalambus,Kathy K Griendling. Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury//Trends Cardiovasc Med. 2007. № 17(2).P.48–54

11. Condliffe A.M., Kitchen E., Chilvers E.R. Neutrophil priming: pathophysiological consequences and underlying mechanisms//Clin Sci (Lond). 1998.№94(5).P.461-71. and inflammation//American journal of physiology.2006. №290 (4).P.622-645

12. Cytochrome p450 epoxygenases and vascular tone: novel role for HMG-CoA reductase inhibitors in the regulation of CYP2C expression/Fleming I. [and others]//Biochim Biophys Acta.2003. №1619.P.332–339

13. Denu JM, Tanner KG. Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation//Biochemistry.1998. №37.P.5633–5642

14. Donato LJ, Noy N. Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling//Cancer Res. 2005. №65.P.8193–8199

15. Dröge W. Free radicals in the physiological control of cell function//Physiol Rev. 2001.№ 82.P. 47–95

16. Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial nitric oxide synthase and soluble guanylate cyclase expression/Bauersachs J. [and others]// Circulation.1999.№100.P.292–298

17. Endothelium-derived hyperpolarizing factor synthase (cytochrome p450 2C9) is a functionally significant source of reactive oxygen species in coronary artery/Fleming I.[and others]//Circ Res.2001. №88.P.44–51

18. Esra Birben, Umit Murat Sahiner, Omer Kalayci. Oxidative Stress and Antioxidant Defense// The World Allergy Organization journal.2012. №5(1).P.9-19

19. Finkel T. Signal transduction by reactive oxygen species in non-phagocytic cells//J Leukoc Biol.1999. №65.P.337–340

20. Fleming I. Cytochrome P450 enzymes in vascular homeostasis//Circ Res.2001. №89.P.753–762

21. Forman H.J.,Torres M. Reactive Oxygen Species and Cell Signaling.Respiratory Burst in Macrophage Signaling// American Journal of Respiratory and Critical Care Medicine. 2002. №166.P.4-8

22. Frantz S.,Bauersachs J.,Ertl G. Post-infarct remodeling contribution of wound healing and inflammation//Cardiovascular Research.2009.№ 81.P.471-481

23. Ghosh R, Mitchell DL. Effect of oxidative DNA damage in promoter elements on transcription factor binding//Nucleic Acids Res.1999. №27.P.3213–3218

24. Goldblatt D, Thrasher AJ. Chronic granulomatous disease//Clin Exp Immunol.2000. №122.P.1–9

25. H2O2-induced O2−• production by a non-phagocytic NAD(P)H oxidase causes oxidant injury/ Li WG[and others]// J Biol Chem.2001. №276.P.29251–29256

26. Henderson LM, Banting G, Chappell JB. The arachidonate-activable, NADPH oxidase-associated H+ channel. Evidence that gp91-phox functions as an essential part of the channel//J Biol Chem.1995.№270.P. 5909–5916

27. Inhibition of cytochrome p450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease/ Fleming I.[and others]//Circulation.2004. №109.P.178–183

28. Jackson AL, Chen R, Loeb LA. Induction of microsatellite instability by oxidative DNA damage// Proc Natl Acad Sci U S A. 1998. №95.P.12468–12473

29. Karen Bedard, Karl-Heinz Krause.The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology//Physiological Reviews. 2007. №87.P.245-313

30. Karen Block, Yves Gorin. Aiding and abetting roles of NOX oxidases in cellular transformation//Nature Reviews Cancer.2012.P.627-637

31. Kathy K. Griendling,Garret A. FitzGerald. Oxidative Stress and Cardiovascular Injury.Part I: Basic Mechanisms and In Vivo Monitoring of ROS//Circulation.2003. №108.P.1912-1916

32. Kovacic HN, Irani K, Goldschmidt-Clermont PJ. Redox regulation of human Rac1 stability by the proteasome in human aortic endothelial cells// J Biol Chem.2001. № 276.P.45856–45861

33. Lefer JD, Granger DN. Oxidative stress and cardiac disease// Am J Med.2000. №109.P.315-338

34. Lenaz G. Role of mitochondria in oxidative stress and ageing//Biochim Biophys Acta.1998. №1366.P.53–67

35. Li J.M, Shah A.M. Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology//Physiol Regul Integr Comp Physiol.2004. №287(5).P.1014-1030

36. Linas ST, Whittenburg D, Repine JE. Role of xanthine oxidase in ischemia/reperfusion injury//Am J Physiol Renal Fluid Electrolyte Physiol.1990. №258.P.711–716

37. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2/Bae YS [and others]//Circ Res. 2009. №104(2).P.210-218

38. Mechanisms of protection of catalase by NADPH. Kinetics and stoichiometry/Kirkman HN. [and others]// J Biol Chem.1999. №274.P.13908–13914

39. Meneshian A and Bulkley GB. The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction//Microcirculation//2002.№9.P.161–175

40. Min Z., Ajay M. Reactive Oxygen Species in Heart Failure//Acute Heart Failure.2008.P. 118-123

41. NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure/Colin E. [and others]// Cardiovascular Research.2006. №71.P.208 – 215

42. Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes/Masella RJ[and others]// Nutr Biochem. 2005.№16.P.577–586.

43. Oxidative Stress, Prooxidants, and Antioxidants: The Interplay /Rahal A [and others]//Biomed Res Int. 2014. р.19

44. Poole LB, Ellis HR. Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase//Methods Enzymol.2002. №348.P.122–136.

45. Priming differentially regulates neutrophil adhesion molecule expression/function/Condliffe A.M. [and others]//Immunology.1996.№ 89(1).P.105–111.

46. Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes / Zorov DB[and others]// J Exp Med.2000. №192.P.1001–1014

47. Rhee SG. Cell signaling. H2O2, a necessary evil for cell signaling//Science.2006.№312. P.1882–1883

48. Role of p47phox in vascular oxidative stress and hypertension caused by angiotensin II /Landmesser U.[and others]// Hypertension.2002. №40.P.511–515

49. Shu Fang Liu,Asrar B. Malik.NF-κB activation as a pathological mechanism of septic shock

50. Sies H. Oxidative stress: Oxidants and antioxidants//Еxperitnental Physiologу.1997. № 82. P.291-295

51. Sun T, Oberley LW. Redox regulation of transcriptional activators//Free Radic Biol Med. 1996. №21.P.335–348.

52. Susin SA, Zamzami N, and Kroemer G. Mitochondria as regulators of apoptosis: doubt no more//Biochim Biophys Acta.1998. №1366.P.151–165

53. TNF-α-induced endothelial cell adhesion molecule expression is cytochrome p-450 monooxygenase dependent/Sasaki M[and others]//Am J Physiol Cell Physiol.2003. №284. P.422–428

54. Whither pathogenetic treatments for diabetic polyneuropathy? /Boulton AJ[and others]// Diabetes Metab Res Rev.2013.№29(5).P.327-33

55. Zhang M., Ajay M. Shah. Reactive Oxygen Species in Heart Failure//Acute Heart Failure. 2008.P.118-123

56. Zhang ZY, Dixon JE. Active site labeling of the Yersinia protein tyrosine certainly help in delineating the role of each compartment of phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402//Biochemistry.1993.№32.P. 9340–9345.

РЕКОМЕНДОВАНО К ЗАЩИТЕ

Зав. кафедрой фармацевтической Г.В. Раменская

и токсикологической химии

Д.ф.н., профессор

Зав. кафедрой патологии С.В. Грачев

академик РАН,

профессор, д.м.н

Зав. Лаборатории Экстремальных состояний НИЦ, Е.И. Асташкин

профессор, д.б.н.

НАУЧНЫЕ РУКОВОДИТЕЛИ:

От кафедры фармацевтической и токсикологической химии:

Доцент, к.ф.н. З. В. Чумакова

От кафедры патологии:

Зав. кафедрой патологии С.В. Грачев

академик РАН,

профессор, д.м.н

От Лаборатории Экстремальных состояний НИЦ:

Зав. Лаборатории Экстремальных состояний НИЦ, Е.И. Асташкин

профессор, д.б.н.

Дата добавления: 2015-07-15