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Clinical manifestations

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The incubation period of poliomyelitis averages from 5 to 14 days; it may sometimes be as short as 2 to 4 days or as long as 35.

Four stages are distinguished in the course of the disease: a) initial or preparalytic, b) paralytic, c) restitution, and d) the stage of residual phenomena.

Preparalytic stage. The disease starts acutely with a marked rise of temperature. Catarrh of the upper respiratory tract (nasopharyngitis, coryza, angina, bronchitis) is present from the first days of the disease. In other cases the onset of the disease is characterized by gastrointestinal disturbances (diarrhea, constipation), sometimes collitic in character.

General symptoms of irritation and functional derangement predominate >n the side of the nervous system (headache, vomiting, dimmed con-iciousness, adynamia, lassitude, drowsiness or insomnia, sometimes deliri-im, tremor, muscular jerking, and convulsions). Convulsions are particularly frequent in nursing babies. Symptoms pointing to irritation of the aerve roots and meninges are seen with great constancy. Flexion of the lead and back, and pressure on the spine are painful, there is pain in the imbs and general hyperesthesia. Rigidity of the occipital muscles and JCernig's, Lasegue's, and Brudzinsky's signs are often found.

The characteristic painfulness of the spine is demonstrable by the "spiral symptom": a sitting patient is unable to touch his knees with his lips oecause of strong pain experienced in the back. To reduce the weight-load on the spine and to render it immobile a sittmg child tries to shift his weight Sind supports himself by the arms (the "tripod" symptoms). The mind re-nnains clear. General and local hyperhidrosis is a particularly frequent manifestation of vegetative derangement

The preparalytic stage usually lasts from 2 to 5 days. In some cases the course of this stage is biphasic with a double peak in the temperature curve, -ever, catarrhal phenomena, or intestinal disturbances are noted, lasting for :Kveral days; brief apyrexia follows, and then a second elevation of temper- Kiture accompanied with general cerebral and meningeal phenomena.

The changes in the cerebrospinal fluid are most constant and charac-.eristic; the fluid is under considerable pressure and is transparent. Globulin jreactions are positive, but protein content is normal or slightly elevated; cell •count is increased due to lymphocytosis, and the number of cells may be as high as 100-200T06/! (100-200 per mm*) or even greater. Thus, a cellular-protein dissociation is characteristically observed during the first five days. Sugar content is normal or slightly elevated. Protein content displays a progressive rise after the fifth day and cell count falls.

Paralytic stage. The temperature falls at the end of the initial stage, and paresis and paralysis occur. Paralysis may develop at the height of the fever, usually suddenly; a child, who had no distinct disturbances of motor function in the evening, may wake up paralysed in the morning ("morning paralysis"). The suddenness, however, is only apparent. Careful examination will have revealed hypotonia, muscular weakness, and loss of reflexes several days previously In the majority of cases paralysis sets in till the fifth day, but may develop much later, on the eighth-tenth day.

Various groups of muscles in the most diverse combinations become involved. The lower limbs are most often affected (58 to 82% of cases); the deltoid muscles come second in order of frequency of implication. Muscles of the trunk and neck, and abdominal and respiratory muscles are less commonly affected. Spinal paralysis may be combinated with lesions of the cranial nerves nuclei (n.facialis is affected in 10 to 12% of cases). Lesions of the abducent, oculomotor, and accessory nerves are less common. The nuclei of vagus, glossopharyngeal and sublingual nerves are also seldom affected, but lesions of these nerves are accompanied with ominous symptoms of disturbance of swallowing and respiration. Isolated cases of paralysis of facial or other cranial nerves are sometimes encountered. Paralysis is usually asymmetrical, and predominantly affects the proximal parts of the extremities.

The paresis and paralysis in poliomyelitis are characterized by signs of damage of the peripheral neuron. The paralysis is flaccid, with loss of muscle tone, little or no active movement, partial or complete degeneration reaction, and absence of tendon reflexes. Cutaneous reflexes (abdominal, on m. cremaster) may also disappear. Muscular atrophy and changes in electric excitability appear one or two weeks after the onset of paralysis, but become more obvious in two or three weeks. The affected limbs are usually cold and cyanotic.

An elevation of protein content and reduction of cell count in cerebrospinal fluid begin in the paralytic stage (from about the fifth day of the disease). Protein-cellular dissociation in the cerebro-spinal fluid is established by the tenth to fourteenth day (an average of 0.65% of protein, cell count being five or six cells per mm3, 5-6T06/l in SI units). Protein content may remain elevated for 40 to 60 days or longer.

The paralytic stage may last several days or one or two weeks, but seldom longer.

Stage of restitution* Restoration of movement in individual groups of muscles usually begins several days after the development of paralysis. The headache and hyperhidrosis abate at the beginning of this stage, and the pain in the spine and limbs also subsides in the majority of cases.

Functional restoration in the paralysed muscles is very rapid at first because some cells were only temporarily affected (as a result of inflammatory edema, vascular changes in the brain matter, or mild reversible lesions in the nerve cells proper). Tendon reflexes reappear or become intensified with the restoration of active movement. But after two months the rate of improvement becomes slower. The stage of restitution may continue for one, two, or three years. Muscles whose function is not recovered become atrophied. Paralytic contractures (chiefly flexion) may develop as a result of uneven affliction and restoration of various muscular groups.

The stage of residual phenomena is characterized by stable flaccid paralysis, atrophy of definite muscular groups, and contractures and deformities of the limbs and trunk.


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