Program

2.1 Brief description of the discipline:

Each new drug is phased manufacturing process, which begins with obtaining drugs in the laboratory and on the production end model or factory installations.

Getting drugs in the laboratory is the longest stage of the production, including a survey and study of the methods of processing of natural or chemical materials, the study of processes of production of intermediate products and methods of their implementation with the least expenditure of energy and resources.

The study of various methods of processing raw materials into intermediate products is possible by combining processes in a group of similar basic typical reaction processes for fine chemicals. In a series of chemical reactions that accompany the process, the chemical processes are introducing substituents in organic compounds: halogenation, sulfonation and sulfohlorirovanie, nitration and nitrosation. The second group of chemical transformations include conversion processes introduced substituents: recovery, diazotization, acylation, esterification, alkylation, arylation, hydrolysis (hydroxylation), ammonolysis, alkaline melting. The third group includes the processes that change the carbon skeleton of the organic compounds (oxidation, reduction, condensation and rearrangement).

In addition to chemical transformations, the process involves physical treatment methods: filtration, precipitation, evaporation, crystallization, drying, distillation, etc.

Thus, the transformation of the intermediate product in the production of the final product is accompanied by a variety of manufacturing operations. Based on the study of processes at the stage of new drugs are taken of the processes that are the most advanced, cost-effective, associated with the use of available and cheap raw materials and hardware design, easier and less phasic subject to the safe conduct and a minimum loss of production of the final product.

2.2 The objective of discipline:

Bring the theoretical knowledge of students in the practical aspects of obtaining drugs.

2.3 Tasks: Discipline teaching shall envisage:

• consolidate students' knowledge on the theoretical foundations of chemistry and technology of drugs;

• to teach the basics of chemical transformations of intermediate or final products of laboratory production;

• to educate students on the basics of physical methods of processing of raw materials;

• to practice the methods of obtaining drugs in the laboratory.

2.4 Training outcomes:

The student should know:

• the main types of chemical reactions used for the synthesis of drugs

• Physical methods of processing raw materials;

• technology of obtaining inorganic drugs;

• technology of obtaining synthetic drugs;

The student shall be able to:

• master the technological stages of obtaining the product production in the laboratory;

• learn practical techniques for the synthesis of intermediates;

• carry out the synthesis of inorganic and organic drugs.

2.5 Prerequisites:

analytical chemistry, physical chemistry, general methods of research and analysis of drugs, physical and chemical methods of research in pharmacy.

2.6 Postrequisites: pharmaceutical chemistry, toxicological chemistry, pharmacognosy.

2.7 Thematic plan: topics, form of teaching and duration of every lesson(practical lessons, student’s self-learning under a teacher’s supervision, student’s self-learning)

Дата добавления: 2015-10-02