Hyaline cartilage

Figure 24. Photomicrograph of a typical hyaline cartilage; DCT, dense connective tissue; P, perichondrium; GC, growing cartilage; N, nuclei; TM, territorial matrix; IM, interterritorial matrix, isogenous groups

Hyaline cartilage is distinguished by a homogeneous, amorphous matrix. The matrix consists of two components: collagen fibrils and ground substance.

In developing bone, the matrix calcifies before it is replaced by bone matrix.

Hyaline cartilage is located in the articular surfaces of the movable joints, in the walls of larger respiratory passages (nose, larynx, trachea, bronchi) in the ventral ends of ribs, where they articulate with sternum, and in the epiphyseal plate, where it is responsible for the longitudinal growth of bone.

Cartilage matrix does calcify.

Cartilage matrix is highly hydrated. From 60% to 78% of the net weight of hyaline cartilage is water.

40% of the dry weight of hyaline cartilage consists of collagen embedded in a firm, hydrated gel of proteoglycans and structural glycoproteins. The collagen component of the matrix is in the form of relatively thin fibrils. The ground substance of hyaline cartilage contains three kinds of glycosaminoglycans:

-hyaluronic acid

-chondroitin sulfate

-keratan sulfate

The chondroitin and keratan sulfates of cartilage are joined to a core protein to form a proteoglycan monomer.

The cartilage matrix surrounding each chondrocyte is rich in glycosaminoglycan and poor in collagen. This peripheral zone, called the territorial or capsular matrix. The cartilage matrix which located between the capsules called the interterritorial matrix.

Except in the articular cartilage of joints, all hyaline cartilage is covered by a layer of dense connective tissue, the perichondrium. The perichondrium appears to be divided into an inner cellular layer, which gives rise to cartilage cells, and an outer fibrous layer.

The cells in the inner layer of the perichondrium are chondroblasts and easily differentiate into chondrocytes.

Chondrocytes are round and may appear in groups of up to eight cells originating from mitotic divisions of a single chondrocyte.

These groups are called isogenous.

Chondrocytes fill the lacunae completely. Chondrocytes synthesize collagen, proteoglycans, hyaluronic acid and chondronectin.

Elastic cartilage

Elastic cartilage is found in the external ear, in the walls of the external auditory canal and the auditory (Eustachian) tube, in the epiglottis and in the larynx. Like hyaline cartilage elastic possesses a perichondrium. The matrix of elastic cartilage does not calcify. Elastic cartilage contains elastic fibers in addition to collagen type II fibrils.

Дата добавления: 2015-07-25