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Type 2 diabetes in newly diagnosed 'can be reversed'?

Newcastle researchers found that the low-calorie diet reduced fat levels in the pancreas and liver, which helped insulin production return to normal. 7 out of 11 people studied were free of diabetes 3 months later. More research is needed to see if the reversal is permanent, say experts.

Type 2 diabetes (adult-onset or non-insulin dependent) develops when not enough insulin is produced in the body or the insulin that is made by the body doesn't work properly. When this happens, glucose builds up in the blood and is not broken down into energy or fuel which the body needs.

The 11 participants in the study were all diagnosed with Type 2 diabetes within the previous 4 years. They cut their food intake for two months, eating only liquid diet drinks and non-starchy vegetables.

After 1 week of the diet, researchers found that the pre-breakfast blood sugar levels of all participants had returned to normal. MRI scans of their pancreases also revealed that the fat levels in the organ had decreased from around 8% - an elevated level - to a more normal 6%. 3 months after the end of the diet, when participants had returned to eating normally and received advice on healthy eating and portion size, most no longer suffered from the condition.

Prof. Roy Taylor said he was not suggesting that people should follow the diet. "This diet was only used to test the hypothesis that if people lose substantial weight they will lose their diabetes. Although this study involved people diagnosed with diabetes within the last four years, there is potential for people with longer-standing diabetes to turn things around too."

However, not everyone in the study managed to stay free of diabetes. Prof. Edwin Gale, a diabetes expert, said the study did not reveal anything new. "We have known that starvation is a good cure for diabetes. If we introduced rationing tomorrow, then we could get rid of diabetes in this country. He added: "If you can catch people with diabetes in the early stages while beta cells are still functioning, then you can delay its onset for years, but you will get it sooner or later because it's in the system."

But Keith Frayn, professor of human metabolism, said the Newcastle study was important: "It offers great hope for many people with diabetes, although it must be said that not everyone will find it possible to start the extremely low-calorie diet used in this study."

1. The article describes an experiment in which a group of patients were offered a diet to return insulin production to normal. Does the article suggest that…

1) the researchers wanted to increase fat levels in the patients’ livers?

2) the patients were not advised to eat potatoes?

3) only those diagnosed with type 2 diabetes took part in the experiment?

4) the experiment lasted 4 years?

5) after the experiment the patients could only eat liquid diet drinks?

6) to monitor the patients’ condition their pre-breakfast sugar levels were measured?

7) MRI was used to see the level of insulin produced?


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