Introduction. Contents 1. Introduction Page 1 2

Contents

1. Introduction	Page 1
2. Methods	Page 1
3. What is stroke	Pages 2-3
4. Available treatments for stroke	Page 4
5. Stem cells	Page 5
6. Mesenchymal stem cells
7. Migratory mechanisms of MSCs
8. MSCs for treatment of stroke
9. Discussion
10. Conclusion
11. References

Introduction

Every year, 15 million people worldwide suffer a stroke. Nearly six million die and another five million are left permanently disabled. (World Heart Federation, 2014) Stroke results from a rapid cessation in adequate amount of blood supply reaching sections of the brain. Presently, the therapies available are: thrombolysis, which is aimed at removing the obstruction by enzymatic digestion of the blood clot and thrombectomy, the surgical removal of the blood clot. However, first clinical trials have confirmed improved functional recovery in stroke patients after receiving bone marrow-derived mesenchymal stem cells systemically. (Doeppner et al, 2010)

This statement is supported by numerous animal studies, which used both human-MSCs and non-human-MSCs; such as those done by: (Mahmood et al., 2005), (Horita et al., 2006), (Lindcall et al., 2004) and (Zheng et al., 2009). (Kim et al., 2013) Also point out the benefits of MSC therapy in humans; however the exact mechanisms of migration of MSCs still remain unclear (Chamberlain et al., 2007). It is essential to understand the molecular mechanisms underlying MSC transfer within the bloodstream, penetration through the vascular wall and tissue invasion in order to develop a functional therapeutic method. The aim of this project is to identify the known migratory mechanisms of mesenchymal stem cells towards ischaemically damaged regions of the brain after systemic delivery and possible modifications improving MSC tropism and homing in the damaged regions.

Methods

Дата добавления: 2015-08-18