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8. de Groot, R., Antibiotic Resistance in Haemophilus influenzas, Rotterdam, Erasmus University, 1991, p13.

9. Jacoby, G.A. and Archer, G.L., "New mechanisms of bacterial resistance to antimicrobial agents", New England Journal of Medicine, Vol 324, No 9, 28 Feb 1991, pp601-12;
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22. de Groot, op cit, pp46-7.

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33. Jackson, D.M. and Soothill, R., Is the Medicine Making You ill?, North Ryde, Australia, Angus & Robertson, 1989, p12.

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35. Levy, op cit, pp335-7.

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41. O'Neill and Mclntosh, op cit, p16.

42. Hamilton-Miller, op cit, ppS206-11.

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44. Anon., "Indiscriminate&qout; antibiotic use in Italy", Scrip, No 1616, 15 May 1991, p8.

45. Harvey, 1988, op cit, pp74-7.

46. Anon., Scrip, No 1313, 1 Jun 1988, op cit, p20.

47. Jones, R.N., "Role of new cephamycins in the management of obstetric and gynecologic infections", Journal of Reproductive Medicine, Vol 35, No 11, (suppl.) Nov 1990, pp1070-7.

48. WHO, The Use of Essential Drugs, (Technical Report Series No 770), Geneva, WHO, 1988, ррЗЗ-4. (The figure excludes drugs for parasitic infections, for leprosy and for tuberculosis.).

49. Parish, op cit, p283.

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53. Salam and Bennish, op cit, pS335.

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55. Anon., Scrip, No 1276, 22 Jan 1988, op cit, p24.

56. Obaseiki-Ebor, E.E., AkereleJ.O. and Ebea, P.O., "A survey of antibiotic outpatient prescribing and antibiotic self-medication", Journal of Antimicrobial Chemotherapy, 1987, pp759-63.

57. Anon., Scrip, No 1355, 26 Oct 1988, op cit, p20.

58. Anon., Scrip, No 1335, 17 Aug 1988, op cit, p21.

59. Antibiotic Guidelines Sub-Committee, Health Dept of Victoria; Antibiotic Guidelines (5th edn), Toorak, Victorian Medical Postgraduate Foundation, 1987, p11.

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61. Obaseiki-Ebor, et al, op cit, pp759-63.

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63. Pratt, W.B. and Fekety, R., The Antimicrobial Drugs, Oxford, Oxford University Press, 1986, p14.

64. Erlichman, J., Gluttons for Punishment, London, Penguin, 1986, p44.

65. Spika, J.S., Blake, P.A. and Cohen, M.L., "Chloramphenicol-resistant Salmonella newport traced through hamburger to dairy farms", New England Journal of Medicine, 3 Sep 1987, p632;
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66. de Groot, op cit, pp20-1.

67. Erlichman, op cit, pp58 and 47.

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69. Piddock, L.J.V., Wray, C., et al; "Quinolone resistance in Salmonella spp: veterinary pointers", Lancet, 14 Jul 1990, p125.

70. Anon., "8% growth for anti-infective market", Scrip, No 1791, 2 Feb 1993, p25.

71. Scrip's 1991 Antibacterial Report, London, PJB Publications, 1991 (One source estimates that the market will be worth more than $25 billion by 1995; see: Anon., "Searle launches Maxaquin in Mexico", Scrip, No 1598, 13 Mar 1991, p22.

72. Geddes, op cit, pp286-9; Liss, R.H. and Batchelor, F.R., "Economic evaluations of antibiotic use and resistance - a perspective: report of Task Force 6", Reviews of Infectious Diseases, Vol 9 (Suppl. 3), May-Jun 1987, ppS297-312.

73. Frieden and Mangi, op cit, pp1438-40; also reported in: Anon., "Overuse ofciprofloxacin in US?", Scrip, No 1558, 17 Oct 1990, p26.

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78. Anon., "Drug promotional problems", Medical Journal of Australia, Vol 150, 17 Apr 1989, p463.

79. Scrip's 1990AntibacterialReport,London, PJS Publications, 1990.

80. Anon., "Top 20 branded products of 1988", Scrip, No 1481, 19 Jan 1990, p24 (based on estimates reported in Flemings Research's Pharmaceutical Products Worldwide);
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81. Parish, op cit, p286.

82. IFPMA, IFPMA Code of Pharmaceutical Marketing Practices, Geneva, IFPMA, 1989, p6.

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84. BMA and the Royal Pharmaceutical Society of Great Britain, British National Formulary, London, BMA and The Pharmaceutical Press, No 22, Sep 1991, p196.

85. Scrip's 1990 Antibacterial Report, op cit.

86. Anon., "European antibiotic mkt projections", Scrip, No 1591, 15 Feb 1991, p6 (citing a 1991 Frost & Sullivan report, The European market for antibiotic products).

87. Gentry, L.O., "Newer concepts in antimicrobial therapy", Clinical Orthopaedics and Related Research, No 261, Dec 1990, pp23-6.

88. AMA, Drug Evaluations, Philadelphia, W.B. Saunders Co., (4th edn) 1980, p1230.

89. AMA, Drug Evaluations, Philadelphia, W.B. Saunders Co., (6th edn) 1986, p1344.

90. Smith, G.H., "Oral cephalosporins in perspective", DICP, The Annals of Pharmacotherapy, Vol 24, Jan 1990, pp45-51.

91. Czachor and Gleckman, op cit, pp169-176.

92. Antibiotic Guidelines Sub-Committee, op cit, p15.

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96. AMA, 1986, op cit, p1369.

97. Advertisement in Thailand Index of Medical Specialities, Vol 17, No 3, Nov 1988, facing р212.

98. Anon., "Hoechst pharma analysed", Scrip, 25 Nov 1985, p7.

99. Anon., "Hoechst's 1990 pharma sales up 2%", Scrip, No 1619, 24 May 1991, p10.

100. Advertisement in Quereshi, A.H. (ed.), Quick Index of Medical Preparations, Nos 1 & 2, Mar-Aug 1990, facing p2A.

101. Ibid, facing p93.

102. Neu, op cit, pp276-85.

103. DiNubile. MJ., "Antibiotics: the antipyretics of choice?", American Journal of Medicine, Vol 89, Dec 1990, pp787-8.

104. Liu, op cit, pp745-74.

105. Anon., Scrip, No 1598,13 Mar 1991, op cit, p22.

106. Аnon., Scrip, No 1591, 15 Feb 1991, op cit, p6.

107. Frieden and Mangi, op cit, pp1438-40; reported in: Anon., Scrip, No 1558, 17 Oct 1990, op cit, p26; and in: Anon., "Quinolones: costs and benefits", Drug Monitor (Philippines), Vol VI, No. 4, Apr 1991, p42.

108. Tan, M.L., Dying for Drugs: Pill power and politics in the Philippines, Manila, Health Action Information Network, 1988, pp142-3.

109. Advertisement in Thailand Index of Medical Specialities, op cit, facing p234.

110. Advertisement in MIMS Africa, Vol 31, No 4, Jul 1991, p73.

111. Anon., "Top 50 branded products worldwide", Scrip, Review issue 1990, p21 (based on Barclay de Zoete Wedd's Pharmaceutical Industry Perspectives).

112. Steele and Kearns, pp1321-49.

113. Rodriguez and Wiedermann, op cit, pp183-210.

114. Hooper, D.C. and Wolfson, J.S., "Fluoroqumolone antimicrobial agents", Neva England Journal of Medicine, Vol 324, No 6, 7 Feb 1991, pp384-94.

115. Advertisement in MIMS India, Vol 8, No 2, Feb 1988, p83.

116. Neu, op cit, pp276-85.

117. Yeung, K.H. and Dillon, J.R., "Norfloxacin resistant Neisseria gonorrhoeae in North America", Lancet, Vol 336, No 8717, 22 Sep 1990, p759;
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118. Hedin, G. and Hambraeus, A., "Multiply antibiotic-resistant Staphylococcus epidermidis in patients, staff and environment - a one-week survey in a bone marrow transplant unit", Journal of Hospital Infection, Vol 17, 1991, pp95-106.

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120. Anon., "Emerging ciprofloxacin resistance", Scrip, No 1566, 14 Nov 1990, p28.

121. Muder, R.R., Brennen, C., et al, "Association with prior fluoroquinolone therapy of widespread ciprofloxacin resistance among gram-negative isolates in a Veterans Affairs medical center", Antimicrobial Agents and Chemotherapy, Vol 35, No 2, Feb 1991, pp256-8.

122. Steele and Kearns, op cit, pp1321-49.

123. Liu, op cit, pp745-74.

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127. Advertisement in Drug Index for Malaysia & Singapore, Vol 15, No 2, Jun 1986, facing p16.

128. BMA and the Royal Pharmaceutical Society of Great Britain, op cit, p205.

129. AMA, 1986, op cit, p1405.

130. Advertisement and product listing in Philippine Index of Medical Specialities, Vol 17, No 3, Dec 1988, pp217-18.

131. Ibid, p216.

132. Scrip’s 1990 Antibacterial Report, op cit.

133. Parish, op cit, pp290-1.

134. Hu, D.-N., Qiu, W.-Q., et al, "Genetic aspects of antibiotic induced deafness: mitochondrial inheritance", Journal of Medical Genetics, Vol 28, 1991, pp79-83.

135. Wilson, S.E., "Aminoglycosides: assessing the potential for nephrotoxicity", Surgery, Gynecology & Obstetrics, Vol 171 (Suppl.), 1990, pp24-30.

136. AMA, 1986, op cit, p1434.

137. Steele and Kearns, op cit, pp1321-49.

138. Neu, op cit, pp276-85; Bergogne-Berezin, E., "Current trends and new perspectives in antibiotic therapy", Journal of Chemotherapy, Vol 1, No 5,1989, pp285-92.

139. BMA and the Royal Pharmaceutical Society of Great Britain, op cit, p202.

140. WHO, 1988, op cit, p35.

141. BMA and the Royal Pharmaceutical Society of Great Britain, op cit, p203.

142. Parish, op cit, p291.

143. BMA and the Royal Pharmaceutical Society of Great Britain, op cit, p36.

144. AMA, 1986, op cit, p1446.

145. Reynolds, J.E.F. (ed.), Martindale: The Extra Pharmacopoeia, London, The Pharmaceutical Press, (29th edn) 1989; BMA and the Royal Pharmaceutical Society of Great Britain, op cit; AMA, 1986, op cit.

146. Cawson, R. and Spector, R., Drugs and Medicines: a consumers' guide, Oxford, Oxford University Press, 1990, p37.

147. BMA and the Royal Pharmaceutical Society of Great Britain, op cit, p206.

148. Parish, op cit, p292.

149. Dunne, M., et al, "Indications and warnings about chloramphenicol", Lancet, 6 Oct 1973, pp781-3.

150. Wolfe, et al, op cit, p343.

151. Advertisement and product listing in Philippine Index of Medical Specialities, Vol 17, No 3, Dec 1988, p175.

152. Pecoul, et al, op cit, pp862-6.

153. Enenkel and Stille, op cit, p14.

154. BMA and the Royal Pharmaceutical Society of Great Britain, op cit, p200.

155. Parish, op cit, p290.

156. Advertisement in Drug Index for Malaysia and Singapore, Vol 15, No2, Jun 1986, facing p189.

157. A.G., Rail, T.W., Nies, A.S., and Taylor, P., Goodman and Gilman’s The Pharmacological Basis of Therapeutics, New York, Pergamon Press, (8th edn) 1990, p1122 (quoting a 1977 study by Fanning, W.L., et al, "Side effects of minocycline: a double-blind study", Antimicrobial Agents and Chemotherapy, Vol 11, 1977, pp712-17).

158. Advertisement in Thailand Index of Medical Specialities, Vol 17, No 3, Nov 1988, facing p230.

159. Liu, op cit, pp745-74.

160. Letter from MaLAM to Lederle Laboratories, Feb 1991.

161. Hollister, L.E. (ed.), 1988 Year Book of Drug Therapy, Chicago, Year Book Medical Publishers, 1988, p191.

162. de Groot, op cit, pp35-7, 53-4.

163. WHO, The World Drug Situation, Geneva, WHO, 1988, p19.

164. de Groot, op cit, pp35-6.

165. Pauly, D.J., Musa, D.M., et al, "Risk of nephrotoxicity with combination vancomycin-aminoglycoside antibiotic therapy", Pharmacotherapy, Vol 10, No 6, 1990 pp378-82.

166. WHO, 1988, op cit.

167. Steele and Kearns, op cit, pp1321-49.

168. French, G. and Ling, Т., "Amoxycillin/clavulanic acid resistant Escherichia coli", Lancet, 26 Mar 1988, p704.

169. Anon., Scrip, No 1296, 1 Apr 1988, op cit, p18.

170. Wyatt, et at, op cit, pp441-4.

171. Geddes, op cit, pp286-9.

172. Anon., "WHO proposes Oreserve antibiotics", Scrip, No 1493, 2 Mar 1990, p28.

173. Friedman, R.B. and Katt,J.A., "Cost-benefit issues in the practice of internal medicine", Archives of Internal Medicine, Vol 151, Jun 1991, pp1165-8.

174. Bergeron, M.G., "The future of new oral antibiotics including the quinolones", Canadian Medical Association Journal, Vol 138, 1 Jan 1988, pp35-42.

175. Midtvedt, Т., "Increasing worldwide microbial resistance: a worldwide responsibility for all, including the pharmaceutical industry and the World Health Organisation", in Dukes, M.N.G. and Beeley, L. (eds), Side Effects of Drugs Annual 12, Amsterdam, Elsevier, 1988, pp206-8.

176. Jacoby and Archer, op cit, pp601-12.

177. Wise, R., "Antimicrobial agents: a widening choice", Lancet, 28 Nov 1987, pp1251-4.

178. Hamilton-Miller, op cit, ppS206-11.

179. Levy, op cit, pp335-7.

180. Hamihpn-Mlller, op cit, ppS206-11.

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