Starch Olygosaccharide Maltose Glucose

Module 1

Lecture N5

Theme:

Common notions about qualitative nutrition diet. Carbohydrates, Lipids and Proteins digestion in the gastrointestinal tract. Absorption ways for products of digestion. Protein putrefaction in the large intestine. Nitrogen balance.

Carbohydrates Digestion in Gastrointestinal Tract

Food sources for carbohydrates:

Starch is represented in several food products, Glycogen is in the liver and muscles of animals. Lactose is in the milk, and sucrose is in sugar.

Digestion of starch and glycogen begins in the oral cavity. Salivary amylase is the main enzyme to destroy α–1,4-glycoside bonds in the structure of polysaccharides (pH _opt =6-8):

(C₆H₁₀O₅)_n (C₆H₁₀O₅)_n-3 + C₁₂H₂₂O₁₁ + C₆H₁₂O₆

Starch Olygosaccharide Maltose Glucose

The second stage of digestion begins in the small intestine, only. That is because gastric juice has very low pH. The digestion of carbohydrates is stopped in the stomach.

Pancreatic amylase (pH_opt =8-8,4) continues the digestion in the small intestine, cleaving the same type of bond (α –1,4- glycoside). But you know that there is another type of bond: α –1,6 glycoside in the structure of oligosaccharides. It is destroyed by oligo-1,6-glycosidase and amylo-1,6-glycosidase produced by mucosa cells.

Cellulose is composed of chains of β–D-glucose units joined by β–1,4 –glycoside bonds. There is no any enzyme in GIT to destroy cellulose. But it is very important in the food digestion for GIT because cellulose is used in the formation of chymus volume to promote normal smooth muscles contraction in GIT.

Maltose is destroyed due to maltase (products: 2 moles of glucose).

Sucrose is destroyed due to sucrase (products: 1 mole of glucose and 1 mole of fructose).

Lactose is destroyed due to lactase (products: 1 mole of glucose and 1 mole of galactose). All these enzymes are produced by mucosa cells of the small intestine.

The end-products of carbohydrates digestion in GIT are monosaccharides that are absorbed usually due to the active transport mechanism (Na⁺,K⁺-ATP pump). Glucose and galactose are absorbed faster then others. The time of the whole digestion of a portion of the food, containing carbohydrates, and their products absorption is about one hour. The essential hyperglycemia occurs after glucose absorption in the small intestine. Hyperglycemia: the concentration of glucose in the blood plasma is higher then 6, 11 mmol/lit (higher then 100mg%).

Then we have to consider some catabolic and anabolic pathways of glucose utilization in tissues controlled by hormone insulin.

Дата добавления: 2015-11-14