Nucleophilic substitution of the halogen in the 4,5-dichloropyridazine-3-one (capitals)

1.Title

Nucleophilic substitution of the halogen in the 4,5-dichloropyridazine-3-one (capitals)

2.Objectives

Current? Interest to the in chemistry pyridazines related to their widespread use medicine and agriculture. Lot of them some are herbicides that are used in agriculture to protect plants from pests. In pharmaceutical chemistry it is used for different types of drugs that are used to treat cardiovascular disease and viral diseases, to eliminate the allergic effects as blockers and more.

3.Research goals

The main objective is to find and work out methods for the selective substitution of halogen in pyridazine cycle.. Also alkylated at the nitrogen atom in pyridazine cycle, which opens a wide range of application of this molecule (one molecule?).

4.Expected results

Expected to prepare substituted 4,5-dichloropyridazin-3-one in fifth position different amines (primary, secondary), mercaptans; N-substituted pyridazine cycles. More chemistry, applications,

5.Grafical abstract Format, Formula, Please, shorten.

Дата добавления: 2015-11-05