Thomson Reuters Web of Science™ 1 страница

FN	Thomson Reuters Web of Science™
VR	1.0

PT	J
AU	Huoviala, Paavo Rantala, Markus J.
TI	A Putative Human Pheromone, Androstadienone, Increases Cooperation between Men
SO	PLOS ONE
VL
IS
AR	e62499
DI	10.1371/journal.pone.0062499
PD	MAY 22 2013
PY
AB	Androstadienone, a component of male sweat, has been suggested to function as a human pheromone, an airborne chemical signal causing specific responses in conspecifics. In earlier studies androstadienone has been reported to increase attraction, affect subjects' mood, cortisol levels and activate brain areas linked to social cognition, among other effects. However, the existing psychological evidence is still relatively scarce, especially regarding androstadienone's effects on male behaviour. The purpose of this study was to look for possible behavioural effects in male subjects by combining two previously distinct branches of research: human pheromone research and behavioural game theory of experimental economics. Forty male subjects participated in a mixed-model, double-blind, placebo-controlled experiment. The participants were exposed to either androstadienone or a control stimulus, and participated in ultimatum and dictator games, decision making tasks commonly used to measure cooperation and generosity quantitatively. Furthermore, we measured participants' salivary cortisol and testosterone levels during the experiment. Salivary testosterone levels were found to positively correlate with cooperative behaviour. After controlling for the effects of participants' baseline testosterone levels, androstadienone was found to increase cooperative behaviour in the decision making tasks. To our knowledge, this is the first study to show that androstadienone directly affects behaviour in human males.
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SN	1932-6203
UT	WOS:000320362700003
ER

PT	J
AU	Cervia, Davide Cataloni, Elisabetta Belardinelli, Maria Cristina Perrotta, Cristiana Picchietti, Simona Alimenti, Claudio Casini, Giovanni Fausto, Anna Maria Vallesi, Adriana
TI	The protein pheromone Er-1 of the ciliate Euplotes raikovi stimulates human T-cell activity: Involvement of interleukin-2 system
SO	EXPERIMENTAL CELL RESEARCH
VL
IS
BP
EP
DI	10.1016/j.yexcr.2012.10.007
PD	FEB 1 2013
PY
AB	Water-soluble protein signals (pheromones) of the ciliate Euplotes have been supposed to be functional precursors of growth factors and cytokines that regulate cell-cell interaction in multi-cellular eukaryotes. This work provides evidence that native preparations of the Euplotes raikovi pheromone Er-1 (a helical protein of 40 amino acids) specifically increases viability, DNA synthesis, proliferation, and the production of interferon-gamma, tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-2, and IL-13 in human Jurkat T-cells. Also, Er-1 significantly decreases the mRNA levels of the beta and gamma subunits of IL-2 receptor (IL-2R), while the mRNA levels of the alpha subunit appeared to be not affected. Jurkat T-cell treatments with Er-1 induced the down-regulation of the IL-2R alpha subunit by a reversible and time-dependent endocytosis, and increased the levels of phosphorylation of the extracellular signal-regulated kinases (ERK). The cell-type specificity of these effects was supported by the finding that Er-1, although unable to directly influence the growth of human glioma U-373 cells, induced Jurkat cells to synthesize and release factors that, in turn, inhibited the U-373 cell proliferation. Overall, these findings imply that Er-1 coupling to IL-2R and ERK immuno-enhances T-cell activity, and that this effect likely translates to an inhibition of glioma cell growth. (c) 2012 Elsevier Inc. All rights reserved.
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Z8
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Z9
SN	0014-4827
UT	WOS:000314145200006
ER

PT	J
AU	Michaelis, Susan Barrowman, Jemima
TI	Biogenesis of the Saccharomyces cerevisiae Pheromone a-Factor, from Yeast Mating to Human Disease
SO	MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
VL
IS
BP
EP	+
DI	10.1128/MMBR.00010-12
PD	SEP 2012
PY
AB	The mating pheromone a-factor secreted by Saccharomyces cerevisiae is a farnesylated and carboxylmethylated peptide and is unusually hydrophobic compared to other extracellular signaling molecules. Mature a-factor is derived from a precursor with a C-terminal CAAX motif that directs a series of posttranslational reactions, including prenylation, endoproteolysis, and carboxylmethylation. Historically, a-factor has served as a valuable model for the discovery and functional analysis of CAAX-processing enzymes. In this review, we discuss the three modules comprising the a-factor biogenesis pathway: (i) the C-terminal CAAX-processing steps carried out by Ram1/Ram2, Ste24 or Rce1, and Ste14; (ii) two sequential N-terminal cleavage steps, mediated by Ste24 and Axl1; and (iii) export by a nonclassical mechanism, mediated by the ATP binding cassette (ABC) transporter Ste6. The small size and hydrophobicity of a-factor present both challenges and advantages for biochemical analysis, as discussed here. The enzymes involved in a-factor biogenesis are conserved from yeasts to mammals. Notably, studies of the zinc metalloprotease Ste24 in S. cerevisiae led to the discovery of its mammalian homolog ZMPSTE24, which cleaves the prenylated C-terminal tail of the nuclear scaffold protein lamin A. Mutations that alter ZMPSTE24 processing of lamin A in humans cause the premature-aging disease progeria and related progeroid disorders. Intriguingly, recent evidence suggests that the entire a-factor pathway, including all three biogenesis modules, may be used to produce a prenylated, secreted signaling molecule involved in germ cell migration in Drosophila. Thus, additional prenylated signaling molecules resembling a-factor, with as-yet-unknown roles in metazoan biology, may await discovery.
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SN	1092-2172
UT	WOS:000308460300006
ER

PT	J
AU	Marzani, Barbara Pinto, Daniela Minervini, Fabio Calasso, Maria Di Cagno, Raffaella Giuliani, Giammaria Gobbetti, Marco De Angelis, Maria
TI	The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, beta-defensin 2 and tumor necrosis factor-alpha genes
SO	EXPERIMENTAL DERMATOLOGY
VL
IS
BP
EP
DI	10.1111/j.1600-0625.2012.01538.x
PD	SEP 2012
PY
AB	Plantaricin A (PlnA) is a peptide with antimicrobial and pheromone activities. PlnA was synthesized chemically and used as a pure peptide or synthesized biologically using Lactobacillus plantarum DC400 co-cultured with Lactobacillus sanfranciscensis DPPMA174. Cell-free supernatant (CFS) was used as a crude PlnA preparation. As estimated using the 3-(4,5-dimethyl-2-yl)-2,5-diphenyltetrazolium bromide and the 2',7'-dichlorofluorescein diacetate assays, both PlnA preparations increased the antioxidant defenses of human NCTC 2544 keratinocytes. PlnA (10 mu g/ml) had a higher activity than hyaluronic acid or 125 mu g/ml alpha-tocopherol. Effects on the transcriptional regulation of filaggrin (FLG), involucrin (IVL), hyaluronan synthase (HAS2), human beta-defensin-2 (HBD-2) and tumor necrosis factor-alpha (TNF-alpha) genes were assayed. Compared with the control, expression of the FLG gene in NCTC 2544 cells increased in cells treated with hyaluronic acid, 1 or 10 mu g/ml PlnA. Compared with the control, the level of IVL gene expression increased in NCTC 2544 cells treated with 10 mu g/ml PlnA. No significant difference was found between the level of the HAS2 gene expressed by control cells and cells treated with PlnA. Compared with chemically synthesized PlnA, the up-regulation of the HBD-2 gene by CFS was higher. Compared with the control, expression of TNF-alpha decreased in NCTC 2544 cells after treatment with 1 or 10 mu g/ml of chemically synthesized PlnA. In contrast, the level of TNF-alpha was highest in the presence of 10 mu g/ml CFS-PlnA. These findings suggest that the PlnA was positively sensed by human keratinocytes, promoting antioxidant defenses, barrier functions and antimicrobial activity of the skin.
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SN	0906-6705
UT	WOS:000307883900047
ER

PT	J
AU	Marzani, B. Pinto, D. De Angelis, M. Gobbetti, M. Benedusi, A. Giuliani, G.
TI	Antimicrobial peptide pheromone Plantaricin A increases the cellular antioxidant defenses of human keratinocytes and modulates the synthesis of filaggrin, involucrin, beta-defensin 2, and tumor necrosis factor alpha
SO	JOURNAL OF INVESTIGATIVE DERMATOLOGY
VL
MA
BP	S58
EP	S58
SU
PD	MAY 2012
PY
CT	75th Annual Meeting of the Society-for-Investigative-Dermatology
CY	MAY 09-12, 2012
CL	Raleigh, NC
SP	Soc Investigat Dermatol
TC
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Z8
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SN	0022-202X
UT	WOS:000302866900343
ER

PT	J
AU	Sieben, Anna
TI	Heteronormative pheromones? A feminist approach to human chemical communication
SO	FEMINIST THEORY
VL
IS
BP
EP
DI	10.1177/1464700111417664
PD	DEC 2011
PY
AB	I analyse scientific articles on human pheromones from a critical feminist perspective, using new materialist feminist theories, in particular, the work of Judith Butler, Karen Barad and Annemarie Mol. Pheromones were defined by Karlson and Luscher in 1959 as 'substances which are secreted to the outside by an individual and received by a second individual of the same species, in which they release a specific reaction - for example, a definite behavior or a developmental process'. In humans, it remains unclear whether substances act as pheromones. With reference to Butler, I show how heteronormativity as a discourse influences research on two potential human pheromones, androstadienone and estratetraenol. I argue that experiments on these two substances have been set up to combine sex-specificity, heterosexuality and reproduction. In these experiments, only the inconsistent effects of androstadienone and estratetraenol were demonstrated. With reference to Barad, I interpret this inconsistency as an indicator of 'resistant matter'. I argue that in order to experimentally show 'heteronormative pheromones' materialities (pheromones) have to merge with discourse (heteronormativity). Androstadienone and estratetraenol partly refuse this collaboration. Finally, I refer to Mol's concept of multiple realities and discuss whether alternative, non-heteronormative effects of pheromones occur instead.
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SN	1464-7001
UT	WOS:000298353600002
ER

PT	J
AU	Trotier, D
TI	Vomeronasal organ and human pheromones.
SO	European annals of otorhinolaryngology, head and neck diseases
VL
IS
BP
EP
DI	10.1016/j.anorl.2010.11.008
PD	2011-Sep
PY
AB	For many organisms, pheromonal communication is of particular importance in managing various aspects of reproduction. In tetrapods, the vomeronasal (Jacobson's) organ specializes in detecting pheromones in biological substrates of congeners. This information triggers behavioral changes associated, in the case of certain pheromones, with neuroendocrine correlates. In human embryos, the organ develops and the nerve fibers constitute a substrate for the migration of GnRH-secreting cells from the olfactory placode toward the hypothalamus. After this essential step for subsequent secretion of sex hormones by the anterior hypophysis, the organ regresses and the neural connections disappear. The vomeronasal cavities can still be observed by endoscopy in some adults, but they lack sensory neurons and nerve fibers. The genes which code for vomeronasal receptor proteins and the specific ionic channels involved in the transduction process are mutated and nonfunctional in humans. In addition, no accessory olfactory bulbs, which receive information from the vomeronasal receptor cells, are found. The vomeronasal sensory function is thus nonoperational in humans. Nevertheless, several steroids are considered to be putative human pheromones; some activate the anterior hypothalamus, but the effects observed are not comparable to those in other mammals. The signaling process (by neuronal detection and transmission to the brain or by systemic effect) remains to be clearly elucidated.
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SN	1879-7296
UT	MEDLINE:21377439
ER

PT	J
AU	Marazziti, D. Torri, P. Baroni, S. Dell'Osso, M. Catena Consoli, G. Boncinelli, V.
TI	Is Androstadienone a Putative Human Pheromone?
SO	CURRENT MEDICINAL CHEMISTRY
VL
IS
BP
EP
PD	MAR 2011
PY
AB	On the basis of different evidences, androstadienone, a steroid compound produced in the armpit, has been proposed as a human pheromone, although its physiological levels appear too low to induce a response under experimental conditions. For this reason, the majority of researchers in this area puts into question the "legitimacy" of androstadienone, and prefers to consider the axillary extracts in its entirety, like a sort of "medicinal tea", the components of which still remain to be identified, but that taken together may induce a response, or function as a carrier of other active substances. Another option is that androstadienone acts with varying degrees of potency and, at lower concentrations, according to the context and to specific behavioral situations.The aim of this paper is to review all relevant data regarding androstadienone, in order to ascertain whether it may be considered a physiological pheromone and, as such, a possible target of future modulators of some human behaviors.
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SN	0929-8673
UT	WOS:000288988100008
ER

PT

J

AU

Romashchenko, A. V.
Ratushnyak, A. S.
Zapara, T. A.
Tkachev, S. E.
Moshkin, M. P.

RI

Tkachev, Sergey

I-7390-2013

TI

BEHAVIORAL AND ELECTROPHYSIOLOGICAL RESPONSES OF THE TAIGA TICK (IXODES PERSULCATUS) TO SYNTHETIC HUMAN SEX PHEROMONES

SO

ZOOLOGICHESKY ZHURNAL

VL

IS

BP

EP

PD

JUN 2010

PY

AB

Despite the fact that there are a lot of works dedicated to attractants of bloodsucking arthropods, the attractiveness of mammal sex pheromones for ticks has not been practically investigated. The possible attractiveness of synthetic human sex pheromones - osmopherin (female pheromone) and osmopheron (male pheromone) for ticks (Ixodes persulcatus) was investigated. The behavioral test for the olfactory preference permitted to reveal the attractiveness of osmopherin for ticks and the absence of a significant response to osmopheron. The infectious status was determined for ticks (n = 50) in behavioral tests. RNA of tick-borne encephalitis was found in thee cases, DNA of Borrelia burgdorferis s. l.- in 21 ones. The existence of transmissible infection agents in the tick's body did not affect the behavior in the test of olfactory preference. The locomotor activity and infection of ticks were assessed in a special experiment, which showed that the infection (64.7%) was almost twice higher in individuals rising to the maximum height in this test. The electrophysiological investigations permitted to detect a zone in synganglion whose neurons are selectively activated by odors. The data obtained enable to compare responses of ticks to odors and changes in the biophysical parameters of a group of central synganglion neurons. The behavioral responses of ticks and synganglion neurons to odors of repellents and osmopherin were opposite, those to osmopheron were absent.

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0044-5134

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WOS:000280373500004

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PT	J
AU	Rajchard, Josef
TI	The steroids considered as human pheromones
SO	ETHOLOGY ECOLOGY & EVOLUTION
VL
IS
BP
EP
AR	PII 925480121
DI	10.1080/03949370.2010.502327
PD
PY
TC
ZB
Z8
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Z9
SN	0394-9370
UT	WOS:000280771000010
ER

PT	B
AU	Saxton, Tamsin K. Havlicek, Jan
BA	Gregory, IS
TI	A BRIEF INTRODUCTION TO "HUMAN PHEROMONES"
SO	PHEROMONES: THEORIES, TYPES AND USES
SE	Biochemistry Research Trends
BP
EP
PD
PY
AB	The study of pheromones in non-human animals has a long pedigree. In contrast, the existence of human pheromones is controversial, although at its base this controversy may be largely semantic Here we summarise the converging evidence from phylogeny, physiology, and behaviour that suggests that the human axilla may have some kind of communicative function, and that axillary secretions can influence social interactions. We recommend that future work should be channelled by the growing scientific understanding that chemical influences on human behaviour may be dependent upon context and environment
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BN	978-1-61668-283-5
UT	WOS:000286642400008
ER

PT

J

AU

Esteves, Francisco
Arriaga, Patricia
Olsson, Mats
Lundstroem, Johan

RI

Arriaga Ferreira, Patricia

M-5189-2013

OI

Arriaga Ferreira, Patricia

0000-0001-5766-0489

TI

PSYCHOPHYSIOLOGICAL EFFECTS OF A PUTATIVE HUMAN PHEROMONE

SO

PSYCHOPHYSIOLOGY

VL

BP

S103

EP

S103

SU

PD

PY

CT

15th Annual Meeting Portland Marriott Downtown Waterfront

CY

SEP 29-OCT 03, 2010

CL

Portland, OR

SP

Soc Psychophysiolog

TC

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0048-5772

UT

WOS:000280662000565

ER

PT	S
AU	Pikielny, Claudio W.
BE	Litwack, G
TI	DROSOPHILA CHEB PROTEINS INVOLVED IN GUSTATORY DETECTION OF PHEROMONES ARE RELATED TO A HUMAN NEURODEGENERATION FACTOR
SO	VITAMINS AND HORMONES: PHEROMONES
SE	Vitamins and Hormones
VL
BP
EP
DI	10.1016/S0083-6729(10)83011-0
PD
PY
AB	The Drosophila CheBs proteins are expressed in a variety of sexually dimorphic subsets of taste hairs, some of which have been directly implicated in pheromone detection. Their remarkable collection of expression patterns suggests that CheBs have specialized roles in gustatory detection of pheromones. Indeed, mutations in the CheB42a gene specifically alter male response to female-specific cuticular hydrocarbons. Furthermore, CheBs belong to the large ML (MD-2-like) superfamily of lipid-binding proteins and share amino acids with an essential role in the function of human GM2-activator protein (GM2-AP), a protein whose absence results in neurodegeneration and death. As GM2-AP binds specifically to the GM2 ganglioside, we have proposed that CheB42a and other CheBs function by interacting directly with the lipid-like cuticular hydrocarbons of Drosophila melanogaster and modulating their detection by transmembrane receptors. Here I review the current knowledge of the CheB family and discuss possible models for their function. (C) 2010 Elsevier Inc.
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SN	0083-6729
BN	978-0-12-381516-3
UT	WOS:000282301000011
ER

PT	J
AU	Kohl, James V. Kelahan, Linda C. Hoffmann, Heather
TI	Putative Human Pheromones Increase Women's Observed Flirtatious Behaviors and Ratings of Attraction
SO	CHEMICAL SENSES
VL
IS
BP	A112
EP	A112
PD	SEP 2009
PY
CT	31st Annual Meeting of the Association-for-Chemoreception-Sciences
CY	APR 22-23, 2009
CL	Sarasota, FL
SP	Assoc Chemorecept Sci
TC
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Z8
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Z9
SN	0379-864X
UT	WOS:000269196800356
ER

PT	J
AU	Savic, Ivanka Heden-Blomqvist, Ebba Berglund, Hans
TI	Pheromone Signal Transduction in Humans: What Can Be Learned From Olfactory Loss
SO	HUMAN BRAIN MAPPING
VL
IS
BP
EP
DI	10.1002/hbm.20727
PD	SEP 2009
PY
AB	Because humans seem to lack neuronal elements in the vomeronasal organ (VNO), many scientists believe that humans are unable to detect pheromones. This view is challenged by the observations that pheromone-like compounds, 4,16-androstadien-3-one (AND) and oestra-1,3,5(10),16-tetraen-3-ol (EST), activate the human hypothalamus. Whether these activations are mediated via VNO, venous blood or olfactory mucosa is presently unknown. To disentangle between the three alternatives, we conducted activation studies in 12 heterosexual males with chronic anosmia because of nasal polyps. Polyposis hampers signal transduction via the olfactory mucosa without interfering with the VNO or the pheromone transport via venous blood. Twelve healthy men served as controls. Subjects were investigated with (15)O-H(2)O PET during smelling of odorless air (base line), AND, EST, vanillin, and acetone. Smelling of EST activated the anterior hypothalamus in controls, but not anosmics. Neither did the anosmics display cerebral activations with AT D or vanillin. Clusters were detected only with the trigeminal odorant acetone, and only in the thalamus, brainstem, the anterior cingulate, and parts of the sensorimotor cortex. Direct comparisons with controls (controls-anosmics) showed clusters in the olfactory cortex (amygdala and piriform cortex) with AND, vanillin, and acetone, and in the Interior hypothalamus with EST. The observed absence of olfactory and presence of trigeminal activations in anosmics indicates that polyposis primarily affected signal processing via the olfactory mucosa. The anosmics inability to activate the hypothalamus with EST, therefore, suggests that in healthy men EST signals were primarily transmitted via the olfactory system. Hum Brain Mapp 30:3057-3065, 2009. (C) 2009 Wiley-Liss, Inc.
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SN	1065-9471
UT	WOS:000269510200029
ER

PT	J
AU	Frey, Monika Weyers, Peter Pauli, Paul Muehlberger, Andreas
TI	A HUMAN PHEROMONE AS SAFETY SIGNAL?
SO	PSYCHOPHYSIOLOGY
VL
BP	S128
EP	S128
PD	SEP 2009
PY
CT	49th Annual Meeting of the Society-for-Psychophysiological-Research
CY	OCT 21-24, 2009
CL	Berlin, GERMANY
SP	Soc Psychophysiol Res
TC
ZB
Z8
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Z9
SN	0048-5772
UT	WOS:000269744700721
ER

PT	J
AU	Mast, Thomas G. Samuelsen, Chad L.
TI	Human Pheromone Detection by the Vomeronasal Organ: Unnecessary for Mate Selection?
SO	CHEMICAL SENSES
VL
IS
BP
EP
DI	10.1093/chemse/bjp030
PD	JUL 2009
PY
AB	Recently, Foltan and Sedy proposed a hypothesis stating that the adult human VNO is integral to the prevention of inappropriate mate selection. In this commentary, we address the authors' assumption that humans have a functional VNO, that pheromones are detected exclusively by the VNO, and that human pheromones are responsible for negative stimuli during mate selection. After examining the published literature on human vomeronasal function, we argue that their hypothesis is critically flawed. We offer a brief review of the adult human VNO in support of our argument.
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SN	0379-864X
UT	WOS:000266955500009
ER

PT	J
AU	Hummer, Tom A. McClintock, Martha K.
TI	Putative human pheromone androstadienone attunes the mind specifically to emotional information
SO	HORMONES AND BEHAVIOR
VL
IS
BP
EP
DI	10.1016/j.yhbeh.2009.01.002
PD	APR 2009
PY
AB	The putative human pheromone Delta 4,16-androstadien-3-one (androstadienone), a non-androgenic steroid found in sweat and saliva, modulates psychological, physiological and hormonal responses without detection as an odor. To determine the specific psychological processes altered by androstadienone, four studies were completed by 50 men and women after solutions of 250 mu M androstadienone or clove-odor control carrier, on separate days. were applied to their upper lip: (1) face pairs were subliminally presented, with one face neutral and the other happy or angry. Androstadienone accelerated speed to locate a subsequent dot probe appearing on the same side as emotional faces, without affecting overall reaction times, indicating that androstadienone specifically enhanced automatic attention to emotional information. (2) In two Stroop paradigms, emotional or mismatched color words interfered with ink color identification. Androstadienone slowed ink color identification of emotional words, demonstrating greater allocation of attentional resources towards emotional information, with no effect on the cognitive Stroop. (3) To test effects on social cognition, participants performed two working memory tasks with distinct stimuli, neutral faces or shapes. Androstadienone did not alter attention to either the social or nonsocial images. (4) The ameliorative effects of androstadienone on self-reported attentiveness were replicated, consistent with increased attention to emotional visual stimuli. Moreover, androstadienone did not alter positive or negative mood, as participants were alone during testing, which removed emotional stimuli from social interactions with a tester. Taken together, these findings demonstrate that subliminal androstadienone guides psychological resources to specifically engage stimuli with emotional significance and does not alter attention to social or general cognitive information. (C) 2009 Published by Elsevier Inc.
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SN	0018-506X; 1095-6867
UT	WOS:000265342300013
ER

PT	J
AU	Zaviacic, M. Sisovsky, V Zaviacic, T.
TI	Cosmetic perfumes vs. human pheromones (natural chemical scents) of the human female and male in signalling and performing context of their sexual behaviour
SO	BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
VL
IS
BP
EP
PD
PY
AB	Scent communication in man is undoubtedly of importance, although it is unconscious, rather than active, as compared to subhuman primates. Besides human sexual life it also affects a number of further characteristics of human life and its infrastructure including the mother-child relationship, creation of the odour basis of the family with the possibility to identify the family members solely by their odour as well as other parameters investigated thus far.Pheromones have effect upon the selection of a suitable partner of the opposite sex (or of the same sex in homosexual partners). The formation of specifically significant responses during communication between the two sexes, first of all in sexual life and its manifestations, may also be influenced by pheromone-based perfumes or classical cosmetic perfumes, as far as they are selected and used appropriately. The situation is much easier if the partners are of the olfactory type where for both partners the mutual olfactory parameters are the most attractive for their sexual life and its parameters, which significantly contributes to the quality of their overall coexistence (Ref. 29). Full Text (Free, PDF) www.bmj.sk.
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SN	0006-9248
UT	WOS:000269177400006
ER

PT	J
AU	Schaal, Benoist
TI	Human pheromones?
SO	BIOFUTUR
IS
BP
EP
PD	MAR 2008
PY
TC
ZB
Z8
ZS
Z9
SN	0294-3506
UT	WOS:000254693500007
ER

PT

B

AU

Saxton, Tamsin K.
Little, Anthony C.
Roberts, S. Craig

BE

Hurst, JL
Beynon, RJ
Roberts, SC
Wyatt, TD

RI

Roberts, S.	A-2040-2009
Little, Anthony	B-8497-2009

OI

Little, Anthony

0000-0001-9100-1903

TI

Ecological validity in the study of human pheromones

SO

CHEMICAL SIGNALS IN VERTEBRATES 11

SE

CHEMICAL SIGNALS IN VERTEBRATES

VL

BP

EP

DI

10.1007/978-0-387-73945-8_10

PD

PY

AB

Several constituents of human axillary secretions have been proposed as candidate human pheromones, but their influence on human behaviour remains controversial. Here we briefly review the literature on the behavioural effects of candidate compounds, noting that inconsistencies in findings could be due in part to the variation in experimental context and potential lack of ecological validity. We also report results of a pilot study which attempts to overcome these limitations in an ecologically-valid experimental paradigm: a speed-dating event. We tested the effects of 4,1 6-androstadien-3-one within a single speed-dating evening with 25 female and 22 male participants. We found a significant effect of androstadienone on female judgments of male attractiveness, which is consistent with the proposal that androstadienone could act as a modulatory pheromone in humans.

CT

11th International Symposium on Chemical Signals in Vertebrates

CY

JUL 25-28, 2006

CL

Chester, ENGLAND

SP

Univ Liverpool, Fac Vet Sci

TC

ZB

Z8

ZS

Z9

BN

978-0-387-73944-1

UT

WOS:000251798000011

ER

PT	J
AU	Mitropoulos, Constantinos Papachatzopoulou, Adamantia Menounos, Panagiotis G. Kolonelou, Christina Pappa, Magda Bertolis, George Gerou, Spiros Patrinos, George P.
TI	Association study of human VN1R1 pheromone receptor gene alleles and gender
SO	GENETIC TESTING
VL
IS
BP
EP
DI	10.1089/gte.2006.0516
PD	SUM 2007
PY
AB	Pheromones are water-soluble chemicals that elicit neuroendocrine and physiological changes, while they also provide information about gender within individuals of the same species. VN1R1 is the only functional pheromone receptor in humans. We have undertaken a large mutation screening approach in 425 adult individuals from the Hellenic population to investigate whether the allelic differences, namely alleles 1a and 1b present in the human VN1R1 gene, are gender specific. Here we show that both VN1R1 1a and 1b alleles are found in chromosomes of both male and female subjects at frequency of 26.35% and 73.65%, respectively. Given the fact that those allelic differences potentially cause minor changes in the protein conformation and its transmembrane domains, as simulated by the TMHMM software, our data suggest that the allelic differences in the human VN1R1 gene are unlikely to be associated with gender and hence to contribute to distinct gender-specific behavior.
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Z9
SN	1090-6576
UT	WOS:000247927500003
ER

PT	J
AU	Ma, Bennett Carr, Brian A. Krolikowski, Paul Chang, Frank N.
TI	Cytotoxicity of a quinone-containing cockroach sex pheromone in human lung adenocarcinoma cells
SO	CHEMICAL RESEARCH IN TOXICOLOGY
VL
IS
BP
EP
DI	10.1021/tx060166z
PD	JAN 2007
PY
AB	The cytotoxic effects of blattellaquinone (BTQ), a sex pheromone produced by adult female German cockroaches, have been studied using human lung adenocarcinoma A549 cells. 1,4-Benzoquinone (BQ), a toxic chemical implicated in benzene toxicity, was used as a reference compound. Both BQ and BTQ showed comparable toxicity toward A549 cells, with LD50 values estimated to be 14 and 19 mu M, respectively. These two compounds increased the formation of an oxidized fluorescent probe, 2',7'-dichlorofluorescein, but had no effect on the cellular GSSG level. Interestingly, BTQ increased the level of 8-epi-prostaglandin F-2 alpha and was 4-fold more efficient in depleting cellular GSH content than BQ. Of the five GSH adducts of BTQ isolated, three were identified as mono-GSH conjugates, and the other two were di-conjugates. Mass spectrometric and NMR analyses of the di-conjugates showed that the second GSH molecule displaced the isovaleric acid moiety, potentially via a nucleophilic substitution reaction. The ability of BTQ to conjugate a second GSH molecule without quinone regeneration indicated that it may be a more effective cross-linking agent than BQ. Future experiments may be needed to evaluate the overall safety of BTQ before the commercialization of the compound as a cockroach attractant.
TC
ZB
Z8
ZS
Z9
SN	0893-228X
UT	WOS:000243483600010
ER

PT	S
AU	Sreevalsan-Nair, Jaya Verhoeven, Meike Woodruff, David L. Hotz, Ingrid Hamann, Bernd
BE	Stutzle, T Birattari, M Hoos, HH
TI	Human-guided enhancement of a Stochastic local search: Visualization and adjustment of 3D pheromone
SO	ENGINEERING STOCHASTIC LOCAL SEARCH ALGORITHMS: DESIGNING, IMPLEMENTING AND ANALYZING EFFECTIVE HEURISTICS
SE	Lecture Notes in Computer Science
VL
BP
EP
PD
PY
CT	International Workshop on Stochastic Local Search Algorithms
CY	SEP 06-08, 2007
CL	Brussels, BELGIUM
TC
ZB
Z8
ZS
Z9
SN	0302-9743
BN	978-3-540-74445-0
UT	WOS:000250749700014
ER

PT	J
AU	Miller, Michael Craig
TI	Human pheromones.
SO	The Harvard mental health letter / from Harvard Medical School
VL
IS
BP
EP
PD	2006-Nov
PY
TC
ZB
Z8
ZS
Z9
SN	1057-5022
UT	MEDLINE:17285716
ER

PT	J
AU	Lim, Suk-Kyung Tanimoto, Koichi Tomita, Haruyoshi Ike, Yasuyoshi
TI	Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces
SO	APPLIED AND ENVIRONMENTAL MICROBIOLOGY
VL
IS
BP
EP
DI	10.1128/AEM.00749-06
PD	OCT 2006
PY
AB	The drug resistances and plasmid contents of a total of 85 vancomycin-resistant enterococcus (VRE) strains that had been isolated in Korea were examined. Fifty-four of the strains originated from samples of chicken feces, and 31 were isolated from hospital patients in Korea. Enterococcus faecalis KV1 and KV2, which had been isolated from a patient and a sample of chicken feces, respectively, were found to carry the plasmids pSL1 and pSL2, respectively. The plasmids transferred resistances to vancomycin, gentamicin, kanamycin, streptomycin, and erythromycin to E. faecalis strains at a high frequency of about 10(-3) per donor cell during 4 hours of broth mating. E. faecalis strains containing each of the pSL plasmids formed clumps after 2 hours of incubation in broth containing E. faecalis FA2-2 culture filtrate (i.e., the E. faecalis sex pheromone), and the plasmid subsequently transferred to the recipient strain in a 10-min short mating in broth, indicating that the plasmids are responsive to E. faecalis pheromones. The pSL plasmids did not respond to any of synthetic pheromones for the previously characterized plasmids. The pheromone specific for pSL plasmids has been designated cSL1. Southern hybridization analysis showed that specific FspI fragments from each of the pSL plasmids hybridized with the aggregation substance gene (asa1) of the pheromone-responsive plasmid pAD1, indicating that the plasmids had a gene homologous to asa1. The restriction maps of the plasmids were identical, and the size of the plasmids was estimated to be 128.1 kb. The plasmids carried five drug resistance determinants for vanA, ermB, aph(3'), aph(6'), and aac(6')/aph(2'), which encode resistance to vancomycin, erythromycin, kanamycin, streptomycin, and gentamicin/kanamycin, respectively. Nucleotide sequence analyses of the drug resistance determinants and their flanking regions are described in this report. The results described provide evidence for the exchange of genetic information between human and animal (chicken) VRE reservoirs and suggest the potential for horizontal transmission of multiple drug resistance, including vancomycin resistance, between farm animals and humans via a pheromone-responsive conjugative plasmid.
TC
ZB
Z8
ZS
Z9
SN	0099-2240
UT	WOS:000241170300015
ER

PT	J
AU	Pause, B. M.
TI	Human pheromones?
SO	CHEMICAL SENSES
VL
IS
MA
BP	E1
EP	E1
PD	OCT 2006
PY
CT	17th Congress of the European-Chemoreception-Research-Organization (ECRO)
CY	SEP 04-08, 2006
CL	Granada, SPAIN
SP	European Chemorecept Res Org
TC
ZB
Z8
ZS
Z9
SN	0379-864X
UT	WOS:000241091600011
ER

PT	J
AU	Wyart, C. Chen, J. Wilson, S. Webster, W. Khan, R. Sobel, N.
TI	A putative human pheromone induces changes in cortisol, positive mood, physiology, and sexual arousal
SO	CHEMICAL SENSES
VL
IS
MA
BP	E1
EP	E1
PD	OCT 2006
PY
CT	17th Congress of the European-Chemoreception-Research-Organization (ECRO)
CY	SEP 04-08, 2006
CL	Granada, SPAIN
SP	European Chemorecept Res Org
TC
ZB
Z8
ZS
Z9
SN	0379-864X
UT	WOS:000241091600012
ER

PT	J
AU	Wyart, C. Webster, W. Chen, J. McClary, A. Wilson, S. Sobel, N.
TI	Role of the main olfactory epithelium in mediating the effects of a putative pheromone in humans
SO	CHEMICAL SENSES
VL
IS
MA
BP	E43
EP	E43
PD	OCT 2006
PY
CT	17th Congress of the European-Chemoreception-Research-Organization (ECRO)
CY	SEP 04-08, 2006
CL	Granada, SPAIN
SP	European Chemorecept Res Org
TC
ZB
Z8
ZS
Z9
SN	0379-864X
UT	WOS:000241091600162
ER

PT	J
AU	Pearson, Helen
TI	Mouse data hint at human pheromones
SO	NATURE
VL
IS
BP
EP
DI	10.1038/442495a
PD	AUG 3 2006
PY
TC
ZB
Z8
ZS
Z9
SN	0028-0836
UT	WOS:000239455900009
ER

PT	J
AU	Laska, Matthias Wieser, Alexandra Salazar, Laura Teresa Hernandez
TI

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